An imaging system comprising a radiation source and radiation thereby; a detector having an input surface; a monitor configured to display images detected by the detector; a Graphical User Interface (GUI) for determining at least one Region of Interest (ROI) on a displayed image; and a collimator comprising means for modulating intensity of the radiation according to the at least one ROI; wherein the GUI comprises means for displaying detected images and means for determining shape and location of the at least one ROI.