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FORMULATIONS DE MEDICAMENT PRESENTANT UN POTENTIEL D'ABUS REDUIT
专利权人:
SUPERNUS PHARMACEUTICALS; INC.
发明人:
申请号:
EP04751878.2
公开号:
EP1624860B1
申请日:
2004.05.12
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Drug formulations having reduced abuse potential which contain one or more of (1) an agent that has a nasty odor, (2) a bright deterrent/indicator dye and (3) fine insoluble particulate matter. The malodorous agent and dye are in a form which does not affect proper administration of the drug, but the odorous agent creates a nasty odor when the dosage form is crushed or chemically extracted and nasally, by inhalation, orally, buccally or sublingually administered and the dye produces a bright color when crushed and contacted. The fine insoluble particulate matter hinders extraction of the drug from the dosage form and, when crushed, can deter intravenous injection because of the presence of the insoluble particles or hinder injection by blocking an intravenous needle. The bright color of the dye, when extracted, also has a psychologically deterrent effect on intravenous abusers.
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