The invention is directed to a Cell with an antigen recognizing structure comprising the sequence: signalling domain, transmembrane domain, chimeric antigen receptor unit, affinity unit, spacer unit, cross linker unit and antigen recognizing domain wherein the antigen recognizing domain comprises a disulfide bond which is bound to the cross linker unit and wherein affinity unit is bound to the spacer unit and wherein the spacer unit is bound to the cross linker unit.
