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נגזרות פירימידיניל–פירידאזינון
专利权人:
MERCK PATENT GMBH
发明人:
申请号:
IL20309409
公开号:
IL203094A
申请日:
2009.12.31
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
The compound is new. The compound of formula (I), their pharmaceutical useful derivatives, solvate, salts, tautomers and stereoisomers, are new. For formula (I), R 1>; : Ar, benzo-2,1,3-thiadiazolyl or Het, where Ar is selected from phenyl, naphthyl or biphenyl, which are unsubstituted or once, twice or thrice substituted by hal, A, N(R 3>;) 2, [C(R 3>;) 2] nOR 3>;, [C(R 3>;) 2] nN(R 3>;) 2, SR 3>;, NO 2>;, CN, COOR 3>;, CON(R 3>;) 2, NR 3>;COA, NR 3>;SO 2A, SO 2N(R 3>;) 2, S(O) mA, CO-Het, Het, O[C(R 3>;) 2] nN(R 3>;) 2, O[C(R 3>;) 2] nHet, NHCOOA, NHCON(R 3>;) 2, NHCOO[C(R 3>;) 2] nN(R 3>;) 2, NHCOO[C(R 3>;) 2] nHet, NHCONH[C(R 3>;) 2] nN(R3)2, NHCONH[C(R 3>;) 2] nHet, OCONH[C(R 3>;) 2] nN(R3)2, OCONH[C(R 3>;) 2] nHet, CONR 3>;[C(R 3>;) 2] nN(R 3>;) 2, CONR 3>;[C(R 3>;) 2] nHet or COA, and Het is once, twice or thrice saturated or unsaturated or aromatic heterocycles with 1-4 N-, O- or S-atoms or piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, benzimidazolyl, benzotriazolyl, indolyl, benzo[1,3]dioxolyl, indazolyl, azabicyclo[3.2.1]octyl, azabicyclo[2.2.2]octyl, imidazolidinyl, azepanyl or benzo [2,1,3]thiadiazolyl, which are unsubstituted or once, twice or thrice substituted by halide, A, [C(R 3>;) 2] nOR 3>;, [C(R 3>;) 2] nN(R 3>;) 2, SR 3>;, NO 2>;, CN, COOR 3>;, CON(R 3>;) 2, NR 3>;COA, NR 3>;SO 2A, SO 2N(R 3>;) 2, S(O) mA, CO-Het 1>;, [C(R 3>;) 2] nHet 1>;, O[C(R 3>;) 2] nN(R 3>;) 2, O[C(R 3>;) 2] nHet 1>;, NHCOOA, NHCON(R 3>;) 2, NHCOO[C(R 3>;)2] nN(R 3>;) 2, NHCOO[C(R 3>;) 2] nHet 1>;, NHCONH[C(R 3>;) 2] nN(R 3>;) 2, NHCONH[C(R 3>;) 2] nHet 1>;, OCONH[C(R 3>;) 2] nN(R 3>;) 2, OCONH[C(R 3>;) 2] nHet 1>;, [C(R 3>;) 2] nOR 3>;, [C(R 3>;) 2] nNR
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