For example as for this invention, in the patient, the anti- IGF-1R antibody or the IGF connection protein (, that for example the molecular IGF-1R kinase inhibiter (, OSI-906) the remedy effective quantity of the mixed medicine simultaneous or the fact that consecutively it prescribes IGFBP3) which is included, the method tumor of the patient or tumor transfer remedying is offered. For example as for this invention, with the carrier which is allowed pharmacy, the anti- IGF-1R antibody or the IGF connection protein ((, for example IGFBP3), and the low-molecular IGF-1R kinase inhibiter (, OSI-906) it offers also the medicine composition which is included.< Selective figure > Figure 3本発明は、患者に、抗IGF-1R抗体またはIGF結合タンパク質(例えば、IGFBP3)のどちらかと分子IGF-1Rキナーゼ阻害剤(例えば、OSI-906)の混合薬の治療有効量を同時または順次に投与することを含む、患者の腫瘍または腫瘍転移を治療する方法を提供する。本発明は、薬学的に許容される担体と共に、抗IGF-1R抗体またはIGF結合タンパク質((例えば、IGFBP3)、および低分子IGF-1Rキナーゼ阻害剤(例えば、OSI-906)を含む医薬組成物も提供する。【選択図】 図3
