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CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUANTERNARY AMMONIUM SALT STRUCTURE
专利权人:
Ltd.;Beijing Showby Pharmaceutical Co.
发明人:
Shouming Wen,Zejun Gao,Junyi Wang,Xiaoping Chen
申请号:
US16469457
公开号:
US20200002329A1
申请日:
2017.12.13
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.
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中国工程科技知识中心
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