The use, in the manufacture of a medicament for treating autoimmune diseases, of a combination comprising a benzophenone derivative represented by the general formula 1 or a salt thereof: and one or more immunosuppressing agents wherein the immunosuppressing agent is a metabolic antagonist or steroidal anti-inflammatory drug. Also disclosed is a pharmaceutical composition for the treatment of autoimmune diseases, which comprises a benzophenone derivative represented by the general formula 1 and one or more immunosuppressing agents wherein the immunosuppressing agent is a metabolic antagonist or steroidal anti-inflammatory drug.