The present disclosure provides compositions and methods useful for preventingand treating Zika virus infection. As described herein, the compositions andmethods are basedon development of immunogenic compositions that include virus-like particles(VLPs) whichcomprise one or more Moloney Murine leukemia virus (MMLV) core proteins andinclude oneor more Zika epitopes, such as, for example, from Zika envelope glycoprotein Eand the Zikastructural protein NS1 including variants thereof