Byoung Dae Lee,Ted M. Dawson,Valina L. Dawson,Andrew B. West,Howard Federoff
申请号：
US13508180
公开号：
US20150018301A1
申请日:
2010.11.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinsons disease. Inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration were identified. The presently disclosed subject matter establishes that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for treating Parkinsons disease.
