BAETTIG, URS,BALA, KAMLESH JAGDIS,BUDD, EMMA,EDWARDS, LEE,HOWSHAM, CATHERINE,HUGHES, GLYN,LEGRAND, DARREN MARK,SPIEGEL, KATRIN
申请号：
CA2793392
公开号：
CA2793392C
申请日:
2011.03.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides pyridine and pyrazine derivatives which restoreor enhance the function of mutantand/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia,chronic bronchitis, chronic obstructive pulmonarydisease, asthma, respiratory tract infections, lung carcinoma, xerostomia andkeratocoujunctivitis sire, or constipation (IBS, IBD,opioid induced). Pharmaceutical compositions comprising such derivatives arealso encompassed.
