An anchoring system 10 secures a catheter 8 to the body of a patient and arrests axial movement of the catheter 8 without meaningfully impairing fluid flow through the catheter 8. The anchoring system 10 includes an anchor pad 12 that adheres to the patient's skin and supports a retainer 20. The retainer 20 includes interengaging structure that moves the retainer 20 between an open and a closed position. When in the open position, the retainer 20 can receive a portion of the catheter 8 and be subsequently moved to the closed position. Advantageously, the interengaging structure allows the retainer 20 to receive catheters 8 of various sizes. In some embodiments the interengaging structure includes a latch mechanism 80 having an angled opening 104 and a strap 24. The angled opening 104 is configured to receive the strap 24 when the retainer 20 is in the closed position. The retainer 20 may further include one or more retention mechanisms to further inhibit axial movement of the catheter 8 relative to the retainer 20 when the catheter 8 is secured therein. In an embodiment, the anchoring system 10 includes a mount that allows the retainer 20 to rotate relative to the anchor pad 12.