通過關聯SVCAM和/或SMADCAM的水平差異確定α-4整聯蛋白活性差異的方法

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专利权人:

BIOGEN MA INC.;比奧根瑪公司

发明人:

CHACKERIAN, Alissa, A.

申请号：

HK18115240

公开号：

HK1256157A1

申请日:

2014.02.19

申请国别(地区):

HK

年份:

2019

代理人:

摘要：

Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAdCAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/