WANG, LI FANG,王丽芳,王麗芳,CHEN, HSUAN YING,陈喧应,陳喧應,WU, PEI LING,巫佩玲,巫佩玲
申请号：
TW102142108
公开号：
TWI459975B
申请日:
2013.11.19
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The invention discloses a pharmaceutical composition having a micelle and a transition metal compound drug. The micelle is formed by self-assembly of a comb polymer. The polymer includes polyethylene glycol (PEG), poly-ε-caprolactone (PCL), and polymethacrylic acid (PMAA), wherein PCL is block-bonded to PEG, and PMAA is graft-bonded to PCL. The invention also pertains to a method for producing the composition and use thereof.本發明提出一種醫藥組合物,其含有一微胞、及一過渡金屬化合物藥物。微胞是一梳狀共聚物自組裝形成的,梳狀共聚物含有聚乙二醇、聚己內酯、及聚甲基丙烯酸,而聚己內酯是嵌段連結至聚乙二醇,聚甲基丙烯酸是接枝連結至聚己內酯。過渡金屬化合物藥物是共價連結於梳狀共聚物的聚甲基丙烯酸。本發明亦提出此組合物的製造方法與用途。
