You Han Bae,Eun Seong Lee,Dongin Kim,Yu Seok Youn,Kyung Taek Oh
申请号：
US11897979
公开号：
US08394391B2
申请日:
2007.08.31
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A drug delivery vehicle for targeted delivery of a drug mimics viral properties of size, capsid-like protein capsule, cell-specific entry, toxin release, destruction of infected cells, and migration to neighboring cells. This vehicle, termed a virogel, contains a hydrophobic polymeric core, a hydrophilic inner shell, a hydrophilic outer shell, and a ligand. An illustrative drug-loaded virogel includes poly(L-histidine-co-phenylalanine) as the core, doxorubicin loaded in the core, polyethylene glycol as the inner shell, bovine serum albumin as the outer shell, and folic acid as the ligand.
