MARTIN, JOEL H.,SMITH, ERIC,PAPADOPOULOS, NICHOLAS J.,NOGUERA-TROISE, IRENE,THURSTON, GAVIN,MARTIN, Joel H.,SMITH, Eric,PAPADOPOULOS, Nicholas J.,NOGUERA-TROISE, Irene,THURSTON, Gavin
申请号：
RSP20120366
公开号：
RS52439B
申请日:
2007.12.14
申请国别(地区):
RS
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to biochemistry. Described is isolated human antibody or antibody fragment, which bind human delta-like ligand 4 (HDll4) in a specific way, said human antibody or antibody fragment contains heavy chain variable region (HCVR), which contains three complementarity-determining regions (CDR) of heavy chain, and light chain variable region (LCVR), which contains three CDR of light chain, where said three CDR of heavy chain contain CDR1, CDR2 and CDR3 sequences SEQ ID NO:429 or SEQ ID NO:901, and said three CDR of light chain contain CDR1, CDR2 and CDR3 sequences SEQ ID NO:437 or SEQ ID NO:903, and where said antibody or its fragment binds with epitope within N-end-DSL domain of hDll4. Described is isolated molecule of nucleic acid, coding described antibody or its antigen-binding fragment. Presented is expression vector, containing described nucleic acid molecule and system "host-vector" for obtaining described antibody. Described is composition for facilitation of course or inhibition of Dll4-mediated human disease or disorder, containing described antibody or its fragment.EFFECT: claimed is method of obtaining described antibody against human Dll4 or its antigen-binding fragment.25 cl, 16 tbl, 9 exHumano antitelo ili fragment antitela, koji specifično vezuju humani delti-sličan ligand 4 (hD114), navedeno antitelo ili fragment antitela sadrže teški lanac varijabilnog regiona/laki lanac varijabilnog regiona (HCVR/LCVR) koji su izabrani od sledećih parova amino kiselinskih sekvenci SEQ ID NO:429/437 i 901/903.Prijava sadrži još 9 patentnih zahteva.
