A system and method of altering damaged mammalian skin using a multiphoton processes is disclosed. A femtosecond laser initiates a multiphoton event using pulse energies of 2-5 mJ thereby causing multiphoton ablation without damaging surrounding tissue. The laser is focused to the vicinity of a target organelle that occurs naturally within the damaged skin, and is related to the dermatological condition being addressed. The type of organelle depends on the condition being addressed, and may be targeted by the depth beneath the surface of the skin at which it is located. The femtosecond laser beam is focused to an intensity of least 1012 W/cm2 to initiate the multiphoton event transforms the targeted organelle to mitigate the damage to the skin.
