Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies

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专利权人:

Douglas Hanahan

发明人:

Douglas Hanahan,Erkki Ruoslahti

申请号：

US12748249

公开号：

US08598316B2

申请日:

2010.03.26

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof. The present invention further provides a conjugate containing a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of malignant skin and which includes the amino acid sequence CGKRK (SEQ ID NO: 6) or the amino acid sequence CDTRL (SEQ ID NO: 7), or a conservative variant or peptidomimetic of one of these sequences.

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中国工程科技知识中心

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