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COMPOSES DE CETOLACTAME ET SON UTILISATION
专利权人:
ABBOTT GMBH & CO. KG
发明人:
LUBISCH, WILFRIED,HAUPT, ANDREAS,BRAJE, WILFRIED,GENESTE, HERVE
申请号:
CA2548276
公开号:
CA2548276C
申请日:
2004.12.10
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention relates to novel keto lactam compounds, hydrogenated derivativesand tautomers thereof. These compounds have valuable therapeutic propertiesand are particularly suited for treating diseases that respond to themodulation of the dopamine D3 receptor. The keto lactams have general formula(I), wherein: (a) represents a group of formulas (b) or (c), wherein D isbound to the nitrogen atom and W, Rp and Rq have the meanings cited in Claim1; -B- represents a bond or (d), wherein Rm and Rn have the meanings cited inClaim 1; (e) represents a single bond or a double bond; Rv, Rw, Rx and Ry havethe meanings cited in Claim 1; D represents a linear or branched 2 to 10-membered alkylene chain that can have, as chain members, a heteroatom group K,which is selected among O, S, S(O), S(O)2, N-R8, CO-O, C(O)NR8 and/or 1 or 2non-adjacent carbonyl groups and which can have a cycloalkane diyl groupand/or a double or triple bond; (f) represents a saturated or monounsaturatedmonocyclic nitrogen heterocyclic compound having 5 to 8 cyclic members or abicyclic saturated nitrogen heterocyclic compound having 7 to 12 cyclicmembers.
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中国工程科技知识中心
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