The inventions discloses a pharmaceutical composition comprising rottlerin or a pharmaceutically acceptable salt thereof or one or more of its derivatives or a pharmaceutically acceptable salt thereof said derivative having the formulawherein X is selected from the group consisting of CH2, O, N, P, and S R1 and R3 are selected from the group consisting of H, OH, NH2, SH, SO, S-NH-R, NH-R (R selected from the group consisting of alkyl, alkenyl, alkinyl, aryl, phenyl, benzyl, ester, ether, carbonyl, carboxyl, F, Cl, Br, I, H), alkyl, alkenyl, alkinyl, aryl, phenyl, benzyl, ester, ether, carbonyl, carboxyl, F, Cl, Br, I and H R2 is selected from the group consisting of ethanone, acetyl, alkyl, alkenyl alkinyl, aryl, phenyl, benzyl, ester ether, carbonyl, carboxyl, F, Cl, Br, I and H R4 is CO-[(E)CHCH]n-Ph, CN-[(E)CHCH]n-Ph, or COOZ, wherein Z is selected from the group consisting of alkenyl, aryl, and alkyl, alkyl, alkenyl, alkinyl, aryl, phenyl, benzyl, ester, ether, carbonyl, carboxyl, F, Cl, Br, I and H R5, R6, R7 and R8 are selected from the group consisting of methyl, H, P, OH, NH2, SH, SO, S-NH-R, NH-R (R selected from the group consisting of alkyl, alkenyl, alkinyl, aryl, phenyl, benzyl, ester, ether, carbonyl, carboxyl, F, Cl, Br, I, H), alkyl, alkenyl, alkinyl, aryl, phenyl, benzyl, ester, ether, carbonyl, carboxyl, F, Cl, Br, I and H, for use in a method of preventing or treating pulmonary hypertension.
