The present invention relates to a phototherapy device, which is driven by a power supply and includes: a housing, having a top portion, a bottom portion and a handheld portion, where the top portion has a light outlet, the handheld portion connects the top portion and the bottom portion, and the handheld portion has at least one protruding part a light-transmitting plate, which covers the light outlet a light-blocking part, formed into a protruding rim along the circumferential direction of the light outlet an LED module, disposed in the housing and corresponding to the light outlet and a control module, electrically connected to the power supply and the LED module. Accordingly, the phototherapy device according to the present invention is suitable for handheld use.