BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;Taiwan Hopax Chemicals Mfg. Co., Ltd.
发明人:
David J. Yang,Dong-Fang Yu,I-Chien Wei
申请号：
US15414631
公开号：
US20170128579A1
申请日:
2017.01.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method of synthesizing a polysaccharide conjugate used for cancer therapy is provided. The method comprises the following steps. A polysaccharide having at least one reactive functional group is provided. The polysaccharide is reacted with at least one monomeric amino acid having an O-group, such that the at least one monomeric amino acid is covalently bound to the polysaccharide by reacting with the reactive functional group to form an amide bond. At least one metal is conjugated to the at least one monomeric amino acid through the O-group so as to form the polysaccharide conjugate. Furthermore, a method for cancer therapy that uses the polysaccharide conjugate obtained by the method above for treatment is also described.
