10'-fluorinated vinca alkaloids provide enhanced biological activity against MDR cancer cells

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专利权人:

The Scripps Research Institute

发明人:

Boger, Dale L.

申请号：

AU2011218391

公开号：

AU2011218391B2

申请日:

2011.02.09

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

A 10'-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10'-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10'-unsubstituted vinca alkaloid.

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