TILLEKERATNE, VIRANGA,TAYLOR, WILLIAM,FEDORKA, SARA
申请号：
CA2898996
公开号：
CA2898996A1
申请日:
2014.01.21
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
