FRANK GOMBERT,HEIKO HENZE,DANIEL OBRECHT,CHRISTIAN LUDIN,STEVEN J. DE MARCO,KERSTIN MOEHLE,ODILE SELLIER,FRANÇOISE JUNG
申请号：
PT05707463
公开号：
PT1856140E
申请日:
2005.02.17
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
Template-fixed beta-hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 alpha-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These beta-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
