Gwan Sun Lee,Se Chang Kwon,Sung Min Bae,Sung Youb Jung
申请号：
BRPI0012265
公开号：
BRPI0012265B1
申请日:
2000.07.07
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF t o periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) wi th other amino acid.
