DENNIS, MARK S.,RUBINFELD, BONNEE,POLAKIS, PAUL,JAKOBOVITS, AYA
申请号：
ES12167198
公开号：
ES2535637T3
申请日:
2007.10.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Polynucleotide encoding: (i) a humanized monoclonal antibody that binds to STEAP-1, wherein the antibody comprises a heavy chain (HC) comprising: (1) an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 14 (2) an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 15 (3) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 16 and (4) a HC-FR1 comprising the amino acid sequence of SEQ ID NO: 25 and a light chain (LC) comprising: (1) an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 11 (2) an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 12 and (3) an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 13, wherein optionally the light chain comprises: (1) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 90 (2) a light chain region comprising the amino acid sequence of SEQ ID NO: 91 (3) a light chain region comprising the amino acid sequence of SEQ ID NO: 92 (4) a light chain region comprising the amino acid sequence of SEQ ID NO: 93 (5) a light chain region comprising the amino acid sequence of SEQ ID NO: 94 (6) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 95 (7) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 96 (8) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 97 (9) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 98 (10) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 99 (11) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 100 or (12) a region of the light chain comprising the amino acid sequence of SEQ ID NO: 101.Polinucleótido que codifica: (i) un anticuerpo monoclonal humanizado que se une a STEAP-1, en el que el anticuerpo comprende una cadena pesada (HC), que comprende: (1) una HVR-H1 que comprende la secuencia de aminoácidos de SEQ ID NO: 14 (2) una HVR-H2 que comprende la secuencia de aminoácidos de SEQ ID NO: 15 (3)
