WANG ZHUOZHI,MURPHY JOHN,MARQUARDT TOBIAS,MOOSMAYER DIETER
申请号：
NZ61596912
公开号：
NZ615969A
申请日:
2012.03.30
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Discloses a bispecific antibody comprising at least one antigen binding portion that binds to an epitope of human tissue factor pathway inhibitor (SEQ ID NO:1), wherein said epitope comprises one or more residues of Kunitz domain 1 and one or more residues of Kunitz domain 2 and wherein the residue of Kunitz domain 1 comprises one or more residues selected from the group consisting of Asp31, Asp32, Gly33, Pro34, Cys35, Lys36, Cys59, Glu60 and Asn62. Also discloses a bispecific antibody comprising at least one antigen binding portion that binds to an epitope of human tissue factor pathway inhibitor (SEQ ID NO:1), wherein said epitope comprises two amino acid loops linked by a disulfide bridge between residues Cys35 and Cys59 of SEQ ID NO:1 wherein the sequences are as defined in the complete specification.
