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Derivados de aminopirimidina 4,6- disustituidos farmacéuticamente activos como moduladores de las proteínas quinasas
专利权人:
GPC BIOTECH AG
发明人:
CHOIDAS, AXEL,BACKES, ALEXANDER,COTTEN, MATT,ENGKVIST, OLA,FELBER, BEATRICE,FREISLEBEN, ACHIM,GODL, KLAUS,GREFF, ZOLTAN,HABENBERGER, PETER,HAFENBRADL, DORIS,HARTUNG, CHRISTIAN,HERGET, THOMAS,HOPPE, ED
申请号:
ES04786953
公开号:
ES2394436T3
申请日:
2004.09.15
申请国别(地区):
ES
年份:
2013
代理人:
摘要:
Compounds having the general formula (I) in dondeR1, R2 and R4 are each -HR3 is a phenyl sustituidoR5 is a substituted or unsubstituted phenyl sustituidoR6 is selected from the group consisting of: -H, C1-C8 linear or branched alkyl, substituted or unsubstituted aryl, substituted or unsubstituted, heteroarilosustituido or unsubstituted, substituted or unsubstituted heterocyclyl, substituted pyrrolidinyl, C3-C8 cicloalquilosustituido or unsubstituted disubstituted cyclohexyl, cyclopentyl, C5-C12 bicycloalkyl substituted or unsubstituted adamantyl group - (CH2) q- substituted or unsubstituted, q is an integer from 1 to 3 under the proviso Quesi R6 is selected as a methylene group - (CH2) q-, R17 or R19 are selected to seruna methylene chain the group - (CH2) s-, wherein s is an integer from 1 to 3 or a - (CH2) tA-, t is anlnteger 1 to 3 and A is selected from O or N, respectively, and R6 and R17 and R19 or R6 together form unsistema 5- or 8 Miembr os, or R6 represents - (CH2) pZ, wherein p is an integer from 0 to 6 and Zseleccionado the group comprising: substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, -N (R7R8 ), wherein R7 and R8 represent independently of each other -H or C1-C6 linear alkyl substituted oramificado or unsubstituted, or Z is selected from - (CR9R10R11), wherein R9, R10 and R11 sonseleccionados independently of each other the group consisting of: -H, linear or branched C1-C8alkyl substituted or unsubstituted aryl, substituted or unsubstituted or -N (R12R13), where R12 and R13 representanindependientemente each other -H or C1-C6 linear or branched alkyl substituted or unsubstituted, under lasalvedad that if Z represents - (CR9R10R11) as defined above, p is selected for Serun integer from 0 to 6, and if Z is selected from substituted or unsubstituted aryl, substituted heteroaryl or nosustituido, heterocyclyl substituted on or substituted or -N (R7R8) as defined above, p is selected to
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