Monocyclic cyanoenones and methods of use thereof

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专利权人:

TRUSTEES OF DARTMOUTH COLLEGE

发明人:

HONDA, TADASHI,DAVID, EMILIE,MIERKE, DALE

申请号：

ES09800964

公开号：

ES2449396T3

申请日:

2009.07.22

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound of the formula: ** Formula ** in which: R1 is (C8) alkyl, substituted (C8) alkyl, (C8) alkenyl, (C8) alkenyl, (C8) alkynyl, substituted (C8) alkynyl, aralkyl (C18), substituted aralkyl (C18), heteroaralkyl (C18), -L-R10, aralkylidenamino (C12), substituted aralkylidenamino (C12) or cyano； L is substituted (C6) alkanediyl or substituted (C6) alkanediyl R10 is substituted (C8) alkyl, substituted (C8) alkyl, aryl (C12), substituted aryl (C12), substituted aralkyl (C12), substituted (C12) aralkyl, heteroaryl ( C12), substituted heteroaryl (C12), heteroaralkyl (C12), amino, alkylamino (C8), substituted alkylamino (C8), dialkylamino (C8), substituted dialkylamino (C8), hydroxy, alkoxy (C8), alkoxy (C8) substituted , (C8) acyl, substituted (C8) acyl or -C>； = C-R11, R11 is hydrogen, hydroxy, halo, amino, hydroxyamino, cyano, mercapto, thio, (C8) alkyl, substituted (C8) alkyl, alkenyl (C8), substituted (C8) alkenyl, (C8) alkynyl, substituted (C8) alkynyl, substituted (C8) aryl, (C8) aryl, substituted (C8) aralkyl, substituted (C8) aralkyl, (C8) heteroaryl, heteroaralkyl ( C8), acyl (C8), substituted acyl (C8), alkoxy (C8), substituted alkoxy (C8), alkenyloxy (C8), substituted alkenyloxy (C8), alkynyloxy (C8), substituted alkyloxy (C8), aryloxy (C8) ), substituted aryloxy (C8), aralkoxy (C8), substituted aralkoxy (C8), heteroaryloxy (C8), heter oaralkoxy (C8), acyloxy (C8), substituted acyloxy (C8), alkylamino (C8), substituted alkylamino (C8), dialkylamino (C8), substituted dialkylamino (C8), alkoxyamino (C8), alkoxyamino (C8) substituted, alkenylamino (C8), substituted alkenylamino (C8), alkylamino (C8), substituted alkylamino (C8), substituted arylamino (C8), substituted arylamino (C8), aralkylamino (C8), substituted aralkylamino (C8), heteroarylamino (C8), heteroaralkylamino ( C8), alkylsulfonylamino (C8), alkylsulfonylamino (C8) substituted, amido (C8), substituted amido (C8), alkylammonium (C8), alkylammonium (C8) substituted, alkylsulfonium (C8), alkylsul

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