YANG, Jin,KIM, Jin Woong,LEE, Han Kyu,KIM, Jae Hyun,SON, Chang Mo,LEE, kyu hwan,CHOI, Hyung-Ho,KIM, daehoon,HA, Tae-Young,RHEE, Jaekeol,梁鎮,金鎮雄,李漢奎,金在賢,孫昌模,李揆煥,崔亨豪,金大訓,河泰榮,李在杰
申请号：
HK16102795.5
公开号：
HK1214822A
申请日:
2016.03.10
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention relates to a novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient for the prevention and treatment of metabolic disease. The novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention has excellent activities of activating GPR40 protein and promoting insulin secretion accordingly but has no toxicity when co-administered with other drugs. That is, the novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention can be co-administered with other drugs and can promote the activation of GPR40 protein significantly, so that the composition comprising the same as an active ingredient can be efficiently used as a pharmaceutical composition for the prevention and treatment of metabolic disease such as obesity, type I diabetes, type II diabetes, incompatible glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, and syndrome X, etc.
