LOPEZ, OMAR D.,CHEN, QI,BELEMA, MAKONEN,HAMANN, LAWRENCE G.
申请号：
ES10714721
公开号：
ES2524542T3
申请日:
2010.03.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, in which: s is 0 or 1； L is -L1-L2-, in which L1 and L2 are independently selected from: ** Formula ** with the proviso that at least one of L1 and L2 is different from ** Formula ** Y and Y- are independently oxygen (O) or NH； R1 is hydrogen or -C (O) Rx； R2 is hydrogen or -C (O) Ry； Rx and Ry are independently selected from cycloalkyl, heteroaryl, heterocyclyl, alkoxy and alkyl substituted with one or more substituents independently selected from aryl, alkenyl, cycloalkyl, heterocyclyl, heteroaryl, -OR3, -C (O) OR4, -NRaRb and -C (O) NRcRd, in which aryl and heteroaryl may be optionally substituted with one or more substituents independently selected from alkyl, haloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, halogen, cyano, nitro, - C (O) OR4, OR5, -NRaRb , (NRaRb) alkyl and (MeO) (HO) P (O) O- and in which cycloalkyl and heterocyclyl may be optionally condensed with an aromatic ring and may be optionally substituted with one or more substituents independently selected from alkyl, hydroxyl, halogen, aryl, -NRaRb, oxo and -C (O) OR4； R3 is hydrogen, alkyl or arylalkyl； R4 is alkyl or arylalkyl； R5 is hydrogen, alkyl or arylalkyl； Ra and Rb are independently selected from hydrogen, alkyl, cycloalkyl, arylalkyl, heteroaryl, -C (O) R6, -C (O) OR7, -C (O) NRcRd and (NRcRd) alkyl, or alternatively, Ra and Rb , together with the nitrogen atom to which they are attached, form a five or six member ring or a bicyclic ring structure with bridge, wherein said five or six member ring or said bicyclic ring structure with bridge can optionally contain one or two additional heteroatoms independently selected from nitrogen, oxygen and sulfur and may contain one, two or three substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, aryl, hydroxyl, C1 to C6 alkoxy, C1 to C4 haloalkoxy and halogen .Un compuesto de Fórmula (I):**Fórmula** o una de sus sales farmacéuticam
