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Labelled Quinoxaline Derivatives as Multimodal Radiopharmaceuticals and Their Precursors
专利权人:
发明人:
Jean-Michel Chezal,Latifa Rbah-Vidal,Emilie Billaud,Philippe Auzeloux,Jean-Claude Madelmont,Aurélien Vidal,Elisabeth Miot-Noirault,Janine Papon,Aurélie Maisonial
申请号:
US14396879
公开号:
US20150079000A1
申请日:
2013.04.19
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to the compound of formula (I), in which R1 represents Sn(R)3, B(OH)2, B(OR)2, a halogen atom, NO2, a radionuclide or a —N+(R)3 group, where R is a (C1-C6) alkyl group, R2 represents a hydrogen atom or a (C1-C6)alkyl group, R3 represents: a —(CH2CH2O)n2—(CH2)n3—X group, or a —(CH2CH2O)n4—(CH2)n5—Y group with Y representing a —C═C—H, a —N3 or a —Ar—(CH2)n6—(OCH2CH2)n7—X group, and X represents a halogen atom, a radionuclide or a —OSO2R′ group, where R′ is a CF3, CH3, t-Bu, Ph, p-NO2Ph, p-BrPh or p-CH3Ph group, and their addition salts with pharmaceutically acceptable acids, The present invention also relates to pharmaceutical compositions comprising them and to their use in diagnosis, in particular with SPECT or PET imaging and in therapy of melanoma, via targeted radionuclide therapy.
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