#$%^&*AU2015271991A120160121.pdf#####Abstract 1. HATU, DIEA, DMF 11> S NNHN 2. 50% TFA /DCM F 0 TCEP M-N 0 NH NH4 O1-\ NI MNHH 0Cem-CHO OTT, pH4.5 N i NH FIG. 16 In one aspect, there is provided a protein-drug conjugate compound comprising a protein covalently attached by a linker to one or more drug moieties, wherein the linker has a half-life of from 1 hour to 50 hours in phosphate buffered saline at 37 0C. A carbonyl derivative of LU103793 is also described that can be used in a protein-drug conjugate compound comprising an antibody covalently attached by a linker to the drug moiety comprising, consisting or consisting essentially of the carbonyl derivative.
