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Pharmaceutical compositions comprising fesoterodine
专利权人:
Hans-Jürgen Mika;Christoph Arth;Michael Komenda;Fatima Bicane
发明人:
Hans-Jürgen Mika,Christoph Arth,Michael Komenda,Fatima Bicane
申请号:
US12342744
公开号:
US08088398B2
申请日:
2008.12.23
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present application relates to a pharmaceutical granulate comprising Fesoterodine or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable stabilizer, which can be selected from the group consisting of sorbitol, xylitol, polydextrose, isomalt, dextrose, and combinations thereof, and is preferably a sugar alcohol selected from the group consisting of xylitol and sorbitol. The granulate is suitable for incorporation into pharmaceutical compositions comprising a gel matrix formed by at least one type of hydroxypropyl methylcellulose into which the Fesoterodine is embedded and, optionally, further excipients. In certain embodiments, the granulate is formed by a process of wet granulation.
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