NEUTRALIZING ANTI-TETANUS HUMAN MONOCLONAL ANTIBODIES FOR C. TETANI INFECTION, METHOD OF OBTAINING SAID MONOCLONAL ANTIBODIES AND THEIR USE IN IMMUNOTHERAPY FOR ACCIDENTS SUSCEPTIBLE TO TETANUS BACILLUS INFECTION
MORO, Ana Maria,KALIL FILHO, Jorge Elias,ALIPRANDINI, Eduardo
申请号：
PH12019500431
公开号：
PH12019500431A1
申请日:
2019.02.27
申请国别(地区):
PH
年份:
2019
代理人:
摘要：
The present invention relates to human anti-tetanus monoclonal antibodies against C. tetani infection, obtained by genetic engineering techniques using the information about the gene sequence obtained from B lymphocytes in the peripheral blood of persons vaccinated with tetanus toxoid. The genetic information is inserted into vectors used for transfecting mammal cells, with the aim of generating cell lines producing anti-tetanus monoclonal antibodies. Another aspect of the present invention relates to immunological compositions containing said monoclonal antibody, and to the uses thereof for the treatment and/or immunotherapy of tetanus infection.
