LINDSLEY, CRAIG W.,CONN, P. JEFFREY,WOOD, MICHAEL R.,HOPKINS, COREY R.,MELANCON, BRUCE J.,POSLUSNEY, MICHAEL S.,ENGERS, DARREN W.
申请号：
CA2853826
公开号：
CA2853826A1
申请日:
2012.10.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin- 1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1)； synthesis methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
