MEEUSEN, Shelly,DIAZ-DE-DURANA, Yaiza,SPRAGGON, Glen,FILIPPI, Christophe,DIDONATO, Michael
申请号：
CR20190535
公开号：
CR20190535A
申请日:
2018.05.22
申请国别(地区):
CR
年份:
2020
代理人:
摘要：
Current transmission provides antigen proteins for cell transplantation that bind to intracellular signals and are stimulated by high affinity hemoglobin receptors. Antibody proteins from cell transplantation play a role in increasing the anti-inflammatory response of cells and reducing the induced inflammatory effect of treatment,1. Reduce and prevent diseases related to the immune system, such as type 1 diabetes: the current diagnosis provides the cytokine engaged proteins, that bind to and persist in cellular signaling through a high affinity interleukin received The anti cytokine engaged proteins find use in enhancing anti inflammatory cell responses, and reducing Pro inflammatory effects in the treatment, diabetes and prevention of diabetes related disorders such as type 1 diabetesLa presente divulgación proporciona proteínas de anticuerpo injertadas con citocinas que se unen a la señalización intracelular y la estimulan a través de un receptor de interleucina de alta afinidad. Las proteínas de anticuerpo injertadas con citocinas hallan un uso en el aumento de las respuestas celulares antiinflamatorias y en la reducción los efectos pro-inflamatorios en el tratamiento, el alivio y la prevención de trastornos relacionados con el sistema inmunitario tales como diabetes Tipo 1.The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
