Contraceptive peptides derived from the venom of the spider Latrodectus mirabilis, nucleotide sequences to transform a microorganism to produce said peptides； methods to obtain the peptides； pharmaceutical compositions containing thereof and use thereof
Antonio De Miranda;Andrés Rudolphy Fontaine;Fernando Romero Mejia;Raúl Sanchez Gutierrez;Eduardo Bustos Obregón
发明人:
Fernando Romero Mejia,Raúl Sanchez Gutierrez,Eduardo Bustos Obregón,Antonio De Miranda,Andrés Rudolphy Fontaine
申请号：
US13053751
公开号：
US08980842B2
申请日:
2011.03.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is directed to an active agent with contraceptive properties which corresponds to a peptide fragment of the Latrodectus mirabilisi's venom. The peptide generally includes the amino acid sequence of SEQ ID NO 2 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. Furthermore, a pharmaceutical contraceptive composition comprising the peptide fragment and one or more pharmaceutically acceptable vehicles is also described. The peptide fragment and pharmaceutical compositions are useful as a contraceptive and spermicide agent.
