KLEIN, ROBERT D.,MOORE, MARK W.,ROSENTHAL, ARNON,RYAN, ANNE M.
申请号：
CA2246768
公开号：
CA2246768C
申请日:
1997.03.13
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
GDNFR.alpha., GDNFR.alpha. extracellular domain (ECD), GDNFR.alpha. variants,chimeric GDNFR.alpha. (e.g.,GDNFR.alpha. immunoadhesin), and antibodies which bind thereto (includingagonist and neutralizing antibodies)are disclosed. Various uses for these molecules are described, includingmethods to modulate cell activity andsurvival by response to GDNFR.alpha. -ligands, for example GDNF, by providingGDNFR.alpha. to the cell. Alsoprovided are methods for using GDNFR.alpha., GDNF, or agonists thereof,separately or in complex, to treat kidneydiseases.
