Anti-CXCR4 antibodies and antibody-drug conjugates

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专利权人:

Pfizer Inc.

发明人:

HO, Wei-Hsien,LIU, Shu-Hui,PERNASETTI, Flavia Mercer

申请号：

AU2017268595

公开号：

AU2017268595B2

申请日:

2017.11.29

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

#$%^&*AU2017268595B220190822.pdf#####ANTI-CXCR4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES Abstract The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/