Disclosed is a therapeutic formulation suitable for intravenous administration to a subject comprising: an aqueous solution a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles and at least one of a dispersion stabilizing agent wherein the colloidal nano-dispersion of the active agent is dispersed into nanodispersion particles having a mean size of less than 200-nm. In a preferred embodiment the hydrophobic active agent is coenzyme Q10 (CoQ10) and the dispersion stabilizing agent is dimyristoylphosphatidyl choline (DMPC).