The present disclosure provides melon plants exhibiting resistance to powdery mildew, aphids, and cucumber vein yellowing virus (CVYV). In certain embodiments, the invention provides melon plants with powdery mildew, aphid, and CVYV resistance loci located in cis linkage on chromosome 5. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.
