A blood glucose sensing device is provided that comprises a house having an exterior surface and that defines an interior space. The housing is configures to be located within a cardiovascular pathway of a patient. A resonant antenna is located within the interior space defined by the housing. The resonant antenna comprises an inductive reactance and a capacitive reactance. The inductive and capacitive reactance have values that define a blood glucose sensitive resonant frequency such that a resonant frequency of the resonant antenna varies in response to changes in blood glucose levels within the blood in the cardiovascular pathway surrounding the housing.