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PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF OBSSESIVE-COMPULSIVE SPECTRUM DISORDER CAUSED BY NINJURIN 1 DEFICIENCY
专利权人:
SNU R&DB FOUNDATION;EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION
发明人:
KIM, KYU WON,김규원,LE HOANG,리호앙,AHN, BUM JU,안범주,OH, GOO TAEG,오구택,JEON, SE JIN,전세진,KIM, KYU WONKR,LE HOANGVN,AHN, BUM JUKR,OH, GOO TAEGKR,JEON, SE JINKR
申请号:
KR1020130096951
公开号:
KR1014844050000B1
申请日:
2013.08.14
申请国别(地区):
KR
年份:
2015
代理人:
摘要:
The present invention relates to a pharmaceutical composition for treating or preventing obsessive compulsive disorder including the antagonist of N-Methyl-D-aspartate (NMDA) receptor as an active ingredient. More specifically, in the present invention, provided is a pharmaceutical composition for treating and/or preventing the obsessive compulsive disorder caused by Ninjurin 1 deficiency by using memantine or pharmaceutically acceptable salts thereof. According to the present invention, a Ninjurin 1 KO mouse is offered to study the obsessive compulsive disorder as a new model, and memantine which is the antagonist of the NMDA receptor or pharmaceutically acceptable salts thereof is offered and used to newly treat the obsessive compulsive disorder.본 발명은 NMDA 수용체(N-Methyl-D-aspartate receptor) 길항제를 유효성분으로 함유하는, 강박증의 예방 또는 치료용 약학적 조성물에 관한 것이다. 구체적으로, 본 발명은 메만틴(Memantine) 또는 이의 약학적으로 허용가능한 염을 이용하여 Ninjurin1 결핍으로 인한 강박증을 예방 및/또는 치료하기 위한 약학적 조성물을 제공한다. 본 발명에 의하면, 강박증 연구를 위한 새로운 모델로서의 Ninjurin 1 KO 마우스를 제공할 수 있으며, NMDA 수용체 길항제인 메만틴 또는 이의 염을 강박증 치료라는 신규용도로 제공할 수 있다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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