Yeda Research and Development Co. Ltd.;Yeda Research and Development Co. Ltd.
发明人:
Irun R. Cohen,Alexandra Zanin-Zhorov,Guy Tal,Francisco Quintana,Meirav Pisner,Ofer Lider
申请号：
US14221887
公开号：
US20140219979A1
申请日:
2014.03.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.
