TESTA, NATHAN E.,CARRIGAN, CHRISTINA N.,AB, OLGA,TAVARES, DANIEL,WOLF, BENI B.
申请号：
CA2883222
公开号：
CA2883222A1
申请日:
2013.08.30
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1 -based therapies. Methods of using the antibodies to monitor therapy are further provided. The present invention provides methods for detection of FOLRI in a sample and can be used, for example, to stratify patients. Thus, in one embodiment, the invention provides a method of treating a patient having a folate receptor 1 -mediated disease comprising: (a) measuring the shed folate receptor 1 (FOLRI) expression level or FOLR1 on a circuiting tumor cell (CTC) in a sample taken from a patient.
