Lyophilizing or sterilizing machine, comprising a lyophilizing or sterilizing chamber, a plurality of loading planes, having a loading surface disposed inside the chamber and overlapping each other, and a movement apparatus to load on and unload from the loading surface of the loading planes, containers the content of which is to be treated in the chamber. The movement apparatus comprises at least one loading/unloading slider mobile on horizontal guides. The loading planes are associated with vertical movement guides. Each of the loading planes comprises at least two opposite lateral flanks, a plurality of through holes being present on at least one of the lateral flanks in order to house the vertical guides. The through holes define a lateral guide solid with the loading plane, at least one through seating being present between said lateral guide and the loading surface to freely house a respective horizontal guide.
