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IL-18 binding proteins
专利权人:
Tariq Ghayur
发明人:
Tariq Ghayur,Boris Labkovsky,Jeffrey W. Voss,Larry Green,John Babcook,Xiao-chi Jia,James Wieler,Jaspal Singh Kang,Brad Hedberg
申请号:
US12843740
公开号:
US08431130B2
申请日:
2010.07.26
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
来源网站:
中国工程科技知识中心
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