Feng-Jing Chen,Mahesh V. Patel,David T. Fikstad,Huiping Zhang,Chandrashekar Gilyar
申请号：
US15660932
公开号：
US20180125979A1
申请日:
2017.07.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid； a solubilizer, preferably a vitamin E substance； and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharamaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.
