Restricted growth type adenovirus expressing the REIC gene

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专利权人:

国立大学法人 岡山大学;桃太郎源株式会社;漢陽大学校産学協力団

发明人:

公文 裕巳,那須 保友,渡部 昌実,ユン チェオク

申请号：

JP2016523496

公开号：

JP6566214B2

申请日:

2015.05.26

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

An object of the present invention is to provide a conditionally replicating adenovirus having a strong anticancer effect. A conditionally replicating adenovirus to replicate specifically in a cancer cell and express REIC protein or REIC C domain protein, wherein the conditionally replicating adenovirus is obtained by inserting full-length REIC DNA or REIC C domain DNA into a conditionally replicating adenovirus comprising an ITR (inverted terminal repeat) sequence of an adenovirus type 5 genome and insertion of an HRE sequence, an hTERT promoter, a decorin-encoding DNA, and a DNA encoding a peptide comprising an RGD sequence.

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中国工程科技知识中心

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http://www.ckcest.cn/home/